Physical Activity and Prevention of Cardiovascular Disease
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Abstract
Cardiovascular diseases (CVD) represent one of the leading causes of morbidity and mortality in the world and according to the World Health Organization (WHO), coronary heart disease (CHD) remains the leading cause of death worldwide. Current management strategies for CHD primarily rely on pharmacological therapies. However, several evidence indicates that non-pharmacological interventions, particularly dietary, lifestyle modifications and physical activity (PA) programs, represent essential components for CHD management due to their cost effectiveness and favourable safety profiles. The purpose of this brief review is to analyze the beneficial relationship between physical activity and CVD.
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Naghavi M, Kyu HH, Aalipour MA, Aalruz H, Ababneh HS, et al. Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. Lancet. 2025;406:1811-1872. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01917-8/fulltext
Khan MS, Shahid I, Bennis A, Rakisheva A, Metra M, et al. Global epidemiology of heart failure. Nat Rev Cardiol. 2024;21:717-734. Available from: https://doi.org/10.1038/s41569-024-01046-6
Mo L, Qiu F, Liu Y, Zang Y, Chen C. Association of the Mediterranean diet, physical activity and related lifestyle factors on the mortality and major adverse cardiovascular events in patients with coronary heart disease: a systematic review and meta-analysis. Nutrients. 2026;7:2589-2595. Available from: https://doi.org/10.3390/nu18162589
Mick N, Savadogo LGB, Théodore N. Health behaviors to prevent cardiovascular risk: a systematic review. BMC Cardiovasc Disord. 2025;25:28-31. Available from: https://doi.org/10.1186/s12872-025-05345-9
Bonekamp NE, May AM, Halle M, Dorresteijn JAN, van der Meer MG, et al. On behalf of the UCC-SMART study group. Physical exercise volume, type, and intensity and risk of all-cause mortality and cardiovascular events in patients with cardiovascular disease: a mediation analysis. Eur Heart J Open. 2023. Available from: https://doi.org/10.1093/ehjopen/oead057
Zhou Y, Zhou J, Gao H, Liang S, Niu L, et al. A systematic review of clinical practice guidelines for physical activity in patients with coronary heart disease. Cardiology. 2026. Available from: https://doi.org/10.1159/crd/absag005
Peng X, Guo T, Wang X, Wan Y, Peng Y, et al. Explanatory variables of objectively measured 24 h movement behaviors in coronary heart disease patients: a systematic review. Clin Cardiol. 2026;49:e70440. Available from: https://doi.org/10.1002/clc.70440
Pelliccia A, Sharma S, Gati S, Bäck M, Börjesson M, et al. 2020 ESC guidelines on sports cardiology and exercise in patients with cardiovascular disease: the Task Force on sports cardiology and exercise in patients with cardiovascular disease of the European Society of Cardiology (ESC). Eur Heart J. 2021;42:17-96. Available from: https://doi.org/10.1093/eurheartj/ehaa605
Harden JE, David Branch J, Reynolds LJ. Impacts of physical inactivity models on endothelial function: a systematic review. Sports Med. 2025;55:1937-1952. Available from: https://doi.org/10.1007/s40279-025-02238-x
Tian D, Meng J. Exercise for prevention and relief of cardiovascular disease: prognoses, mechanisms, and approaches. Oxid Med Cell Longev. 2019;2019:3756750. Available from: https://doi.org/10.1155/2019/3756750
Fiuza-Luces C, Santos-Lozano A, Joyner M, Carrera-Bastos P, Picazo O, et al. Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors. Nat Rev Cardiol. 2018;15:731-743. Available from: https://doi.org/10.1038/s41569-018-0065-1
Fletcher GF, Balady G, Blair SN, Blumenthal J, Caspersen J, et al. Statement on exercise: benefits and recommendations for physical activity programs for all Americans. Circulation. 1996;94:857-862. Available from: https://doi.org/10.1161/01.cir.94.4.857
Ellingson CJ, Singh J, Shafiq MA, Mehta N, Sultana S, et al. Exercise volume and coronary artery calcification: a systematic review. CJC. 2025;30:457-465. Available from: https://doi.org/10.1016/j.cjco.2025.12.009
Ding H, Jiang L, Seo H, Chun B. Optimal exercise modalities and doses for improving pro-atherogenic lipid profiles in patients with metabolic syndrome: a systematic review with pairwise, network, and dose-response meta-analyses. BMC Med. 2025;24. Available from: https://doi.org/10.1186/s12916-025-04495-z
Toumpourleka M, Stavrakis S. Neuroimmune interactions in cardiovascular homeostasis and disease. Am J Physiol Cell Physiol. 2026;330:819-830. Available from: https://doi.org/10.1152/ajpcell.00541.2025
Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020;54:1451-1462. Available from: https://doi.org/10.1136/bjsports-2020-102955
Leisure-time and occupational physical activity and risk of cardiovascular disease incidence: a systematic-review and dose-response meta-analysis of prospective cohort studies. Int J Behav Nutr Phys Act. 2024. Available from: https://doi.org/10.1186/s12966-024-01593-8
2024 ESC guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024. Available from: https://doi.org/10.1093/eurheartj/ehae177
2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease. J Am Coll Cardiol. 2023. Available from: https://doi.org/10.1016/j.jacc.2023.04.003
2024 ESC guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. 2024. Available from: https://doi.org/10.1093/eurheartj/ehae178
Mohanta SK, Heron C, Klaus-Bergmann A, Horstmann H, Brakenhielm E, et al. Neural mechanisms in cardiovascular health and disease. Circ Res. 2025;136:1255-1280. Available from: https://doi.org/10.1161/circresaha.125.325496